Description

Triethyl 4-Phosphonobutyrate is a high-purity organophosphorus compound, specifically a phosphonate ester, valued for its role as a versatile synthetic intermediate. Its primary commercial significance lies in its use as a key building block in the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical industries. This product is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), novel crop protection agents, and specialty chemicals requiring precise phosphonate functionality.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of bisphosphonate drugs used for treating bone disorders such as osteoporosis.
• Agrochemical Synthesis: Serves as a key building block for creating herbicides, plant growth regulators, and other crop protection agents with phosphonate moieties.
• Organic Synthesis Reagent: Utilized in Horner-Wadsworth-Emmons (HWE) olefination reactions to generate alkenes with high stereoselectivity.
• Ligand and Catalyst Preparation: Used in the development of phosphonate-based ligands for metal catalysis and coordination chemistry.
• Material Science Research: Employed in the synthesis of flame retardants, polymer modifiers, and specialty surfactants.
• Chemical Biology Probes: Acts as a scaffold for developing enzyme inhibitors and molecular probes targeting phosphate-metabolizing pathways.

Basic Information

Product Name	Triethyl 4-Phosphonobutyrate
CAS No.	2327-69-7
Molecular Formula	C10H21O5P
Molecular Weight	252.24 g/mol
Synonyms	4-(Diethoxyphosphoryl)butyric Acid Ethyl Ester; Ethyl 4-(Diethoxyphosphoryl)butyrate; Triethyl (3-Carboxypropyl)phosphonate; Butyric acid, 4-phosphono-, triethyl ester; (4-Ethoxy-4-oxobutyl)phosphonic Acid Diethyl Ester; Diethyl (4-Ethoxy-4-oxobutyl)phosphonate; Phosphonobutyric Acid Triethyl Ester
EINECS	219-040-6

Quality Control

Our Triethyl 4-Phosphonobutyrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatographic purity assays and identity confirmation, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container must be kept tightly sealed due to sensitivity to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20/D)	1.435 - 1.445
Density (g/mL at 20°C)	1.090 - 1.110

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.