Description

Cholan-24-Oic Acid, 12-Hydroxy-3,7-Dioxo-, (5β,12α)- is a high-purity bile acid derivative, specifically a trihydroxy-5β-cholanic acid, that serves as a critical intermediate in advanced pharmaceutical synthesis and biochemical research. Its value lies in its defined stereochemistry and functional groups, which make it an essential building block for producing steroid-based therapeutics and reference standards. This compound is primarily needed by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers focused on metabolic pathway studies, drug discovery, and the production of specialized cholic acid analogs.

Application

• Pharmaceutical Intermediate: A key starting material or intermediate in the synthesis of steroid drugs, hepatoprotective agents, and other therapeutic bile acid derivatives.
• Biochemical Research: Used as a reference standard or probe in studies of bile acid metabolism, liver function, and cholesterol homeostasis.
• Reference Standard: Serves as a high-purity certified reference material (CRM) for analytical method development and quality control in pharmaceutical analysis.
• Fine Chemical Synthesis: Employed in organic synthesis to introduce the cholanic acid skeleton into more complex molecules for various applications.

Basic Information

Product Name	Cholan-24-Oic Acid, 12-Hydroxy-3,7-Dioxo-, (5β,12α)-
CAS No.	2304-92-9
Molecular Formula	C₂₄H₃₈O₆
Molecular Weight	422.56 g/mol
Synonyms	12α-Hydroxy-3,7-dioxo-5β-cholan-24-oic Acid; 3,7,12-Trioxo-5β-cholan-24-oic Acid; 3,7,12-Trioxocholanic Acid; 12α-Hydroxy-3,7-diketocholanic Acid; Dehydrocholic Acid Impurity; 5β-Cholan-24-oic Acid, 12α-hydroxy-3,7-dioxo-; 3,7,12-Trioxo-5β-cholanoic Acid
EINECS	218-973-6

Quality Control

Our Cholan-24-Oic Acid, 12-Hydroxy-3,7-Dioxo-, (5β,12α)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting standards for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.