Description

2-Methoxyphenyl Chloroformate is a versatile and reactive chemical intermediate belonging to the chloroformate ester class. Its primary value lies in its role as a key building block for the synthesis of more complex molecules, particularly in pharmaceutical and agrochemical research and development. This compound is essential for chemists and manufacturers engaged in creating active pharmaceutical ingredients (APIs), fine chemicals, and advanced materials. The product is supplied with a high level of purity and consistency to meet the stringent demands of industrial-scale synthesis.

Application

• Pharmaceutical Intermediate: A critical reagent in the synthesis of various active pharmaceutical ingredients (APIs), particularly for constructing carbamate and carbonate linkages.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides where its methoxyphenyl moiety is incorporated into the final product structure.
• Polymer Chemistry: Serves as a monomer or modifying agent in the production of specialty polymers and resins, including polycarbonates and polyurethanes.
• Peptide & Protein Research: Employed as a protecting group reagent for amino acids during solid-phase peptide synthesis (SPPS).
• Fine Chemical Production: Acts as a foundational material for synthesizing dyes, pigments, and other complex organic compounds.
• Cross-coupling Reactions: Utilized in palladium-catalyzed reactions, such as Suzuki-Miyaura couplings, to introduce the 2-methoxyphenyl group.

Basic Information

Product Name	2-Methoxyphenyl Chloroformate
CAS No.	2293-75-6
Molecular Formula	C8H7ClO3
Molecular Weight	186.59 g/mol
Synonyms	o-Methoxyphenyl Chloroformate; 2-Methoxy Phenyl Chloroformate; (2-Methoxyphenyl) Carbonochloridate; Guaiacol Chloroformate; Chloroformic Acid 2-Methoxyphenyl Ester; Carbonochloridic Acid, 2-Methoxyphenyl Ester; 1-Chlorocarbonyloxy-2-methoxybenzene
EINECS	Contact for details

Quality Control

Our 2-Methoxyphenyl Chloroformate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chromatography (HPLC, GC) and spectroscopic methods (IR, NMR), to verify identity, potency, and impurity profiles. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure containers are kept tightly sealed to exclude moisture. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Density	~1.28 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.