Description

Trimethylsilyl Isothiocyanate is a versatile organosilicon reagent featuring a reactive isothiocyanate group protected by a trimethylsilyl moiety. This compound is valued for its role as a key synthetic building block in the preparation of thiourea derivatives and heterocyclic compounds under mild conditions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for introducing the thiocarbonyl functional group.

Application

• Pharmaceutical Intermediate: Synthesis of thiourea-based drug candidates and bioactive molecules.
• Agrochemical Production: Building block for herbicides, fungicides, and plant growth regulators containing thiocarbonyl groups.
• Polymer Modification: Agent for introducing functional side chains or cross-linking points into polymer backbones.
• Heterocyclic Chemistry: Key reagent in the construction of thiazole, thiadiazole, and other sulfur-nitrogen heterocycles.
• Surface Derivatization: Silanizing agent for modifying silica or other oxide surfaces for specialized chromatography or material science applications.
• Chemical Research: Versatile reagent in organic synthesis for protecting group strategies and novel reaction development.

Basic Information

Product Name	Trimethylsilyl Isothiocyanate
CAS No.	2290-65-5
Molecular Formula	C4H9NSSi
Molecular Weight	131.27 g/mol
Synonyms	(Trimethylsilyl)isothiocyanate; Isothiocyanatotrimethylsilane; TMS-NCS; Trimethylsilyl Isothiocyanide; NSC 163083; Trimethylsilyl mustard oil; (Isothiocyanato)trimethylsilane
EINECS	218-929-7

Quality Control

Our Trimethylsilyl Isothiocyanate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including assay (GC/HPLC), identity confirmation (IR, NMR), and impurity profiling, to ensure high purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 2-8°C (refrigerated) or as specified on the label. Due to its hygroscopic and highly volatile nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.