Description

(S)-5,6,6A,7-Tetrahydro-1,2,9,10-Tetramethoxy-6-Methyl-4H-Dibenzo[De,G]Quinolinium Chloride is a high-purity, chiral tetrahydroprotoberberine alkaloid salt of significant interest in advanced pharmaceutical research and development. This compound serves as a critical pharmacological reference standard and a key synthetic intermediate for the study of complex biological pathways. It is primarily required by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in neuroscience and medicinal chemistry programs.

Application

• Pharmaceutical Reference Standard: Used for the calibration of analytical instruments (HPLC, LC-MS) and the quantification of related alkaloids in research samples.
• Medicinal Chemistry Intermediate: Serves as a chiral building block in the synthesis of novel drug candidates targeting neurological receptors.
• Biochemical Research: Employed in in-vitro studies to investigate interactions with dopaminergic and other central nervous system targets.
• Process Development & Scale-up: Used by fine chemical suppliers to develop and validate synthetic routes for Good Manufacturing Practice (GMP) production.
• Academic Research: A key compound for universities and institutes studying the structure-activity relationships of isoquinoline alkaloids.
• Quality Control Laboratories: Acts as a high-purity comparator for the identity testing of bulk active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(S)-5,6,6A,7-Tetrahydro-1,2,9,10-Tetramethoxy-6-Methyl-4H-Dibenzo[De,G]Quinolinium Chloride
CAS No.	2269-06-9
Molecular Formula	C22H26NO4+ • Cl-
Molecular Weight	403.90 g/mol (for cation C22H26NO4+)
Synonyms	(S)-Corytuberine Methochloride; (S)-Corytuberine Methyl Chloride; (6S)-5,6,6a,7-Tetrahydro-1,2,9,10-tetramethoxy-6-methyl-4H-dibenzo[de,g]quinolinium Chloride; (S)-N-Methylcorytuberinium Chloride; (S)-Corytuberine N-Methochloride; (S)-2,3,9,10-Tetramethoxy-13-methyl-5,6,13,13a-tetrahydro-8H-dibenzo[a,g]quinolizinium Chloride; (S)-Corytuberine Methodide (related iodide salt); NSC 169865
EINECS	Contact for details

Quality Control

Our (S)-5,6,6A,7-Tetrahydro-1,2,9,10-Tetramethoxy-6-Methyl-4H-Dibenzo[De,G]Quinolinium Chloride is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and loss on drying. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing all critical quality attributes to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment. For long-term storage, consider sealing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.