Description

1-(2,4-Difluorophenyl)Ethanol is a versatile fluorinated aromatic alcohol building block of significant importance in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms on the phenyl ring, which can dramatically alter the electronic properties, metabolic stability, and bioavailability of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it serves as a key intermediate for developing active ingredients, including potential antifungal agents and novel crop protection chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for antifungal and antibacterial agents, where the difluorophenyl moiety enhances potency and pharmacokinetic properties.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, leveraging the fluorine atoms to improve biological activity, environmental stability, and selectivity.
• Liquid Crystal & OLED Material Research: Serves as a building block for fluorinated organic electronic materials, where its structure can influence the dielectric anisotropy and stability of liquid crystals or emissive layers in OLEDs.
• Chiral Resolution & Asymmetric Synthesis: The chiral center makes it a valuable starting material or resolving agent for producing enantiomerically pure compounds in fine chemical and catalyst development.
• Polymer Modification: Acts as a monomer or modifier for introducing fluorine-containing aromatic groups into specialty polymers to enhance thermal stability, chemical resistance, or surface properties.
• Cross-Coupling Reactions: Utilized in palladium-catalyzed reactions like Suzuki or Heck couplings to construct complex, fluorinated biaryl structures prevalent in medicinal chemistry.

Basic Information

Product Name	1-(2,4-Difluorophenyl)Ethanol
CAS No.	2267-47-2
Molecular Formula	C8H8F2O
Molecular Weight	158.15 g/mol
Synonyms	2,4-Difluoro-α-methylbenzyl Alcohol; (2,4-Difluorophenyl)methylcarbinol; α-Methyl-2,4-difluorobenzyl Alcohol; 1-(2,4-Difluorophenyl)ethan-1-ol; 2,4-Difluoro-α-phenethyl Alcohol; 1-(2,4-Difluorophenyl)ethyl Alcohol; rac-1-(2,4-Difluorophenyl)ethanol
EINECS	218-872-8

Quality Control

Our production of 1-(2,4-Difluorophenyl)Ethanol adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR to verify identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, and we support customer audits and regulatory documentation requirements for pharmaceutical and agrochemical submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Total impurities ≤ 3.0%
Optical Purity (Chiral HPLC)	Contact for details (racemic or enantiopure grades available)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.