Description

3-(Trifluoromethyl)Benzoyl Chloride is a versatile and highly reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value proposition lies in the introduction of the electron-withdrawing trifluoromethyl group, which significantly alters the physicochemical properties of target molecules, enhancing their metabolic stability and lipophilicity. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require a reliable, high-purity intermediate for constructing complex fluorinated architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing the benzoyl moiety with trifluoromethyl substitution to improve drug-like properties.
• Agrochemical Synthesis: Used in manufacturing advanced herbicides, fungicides, and insecticides where the CF₃ group contributes to biological activity and environmental persistence.
• Liquid Crystal & OLED Material Production: Acts as a building block for fluorinated aromatic cores in electronic materials, influencing dielectric anisotropy and emission characteristics.
• Polymer Chemistry: Employed as a monomer or modifier in the production of specialty polymers, including polyamides and polyesters, to impart chemical resistance and thermal stability.
• Organic Synthesis Reagent: A fundamental reagent for Friedel-Crafts acylation, amide coupling, and esterification reactions to introduce the 3-(trifluoromethyl)benzoyl functional group.
• Dye & Pigment Manufacturing: Intermediate for creating fluorinated dyes and pigments that offer enhanced light fastness and color properties.

Basic Information

Product Name	3-(Trifluoromethyl)Benzoyl Chloride
CAS No.	2251-65-2
Molecular Formula	C₈H₄ClF₃O
Molecular Weight	208.56 g/mol
Synonyms	m-(Trifluoromethyl)benzoyl chloride; 3-(Trifluoromethyl)benzenecarbonyl chloride; α,α,α-Trifluoro-m-toluoyl chloride; m-Trifluoromethylbenzoyl chloride; Benzoyl chloride, 3-(trifluoromethyl)-; 3-Trifluoromethylbenzoyl chloride
EINECS	218-848-9

Quality Control

Our 3-(Trifluoromethyl)Benzoyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis. Keep away from strong bases, oxidizers, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.