Description

5-Azacitidine 5'-Diphosphate is a biologically active nucleotide analog and a key intermediate in the synthesis of nucleoside-based pharmaceuticals. This compound is critical for research and development in epigenetics and oncology, serving as a precursor to active metabolites that modulate DNA methylation. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions focused on developing novel therapeutics for cancer and other epigenetic diseases.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of nucleoside analog drugs, particularly DNA methyltransferase inhibitors like Azacitidine and Decitabine.
• Biochemical Research: Used as a substrate or reference standard in enzymatic studies related to nucleotide metabolism and epigenetic regulation.
• Oncology R&D: Employed in the development and screening of novel chemotherapeutic agents targeting aberrant DNA methylation patterns in cancer cells.
• Enzyme Inhibition Studies: Serves as a tool compound to study the mechanism of action and kinetics of DNA methyltransferases and other nucleotide-processing enzymes.
• Metabolite Standard: Acts as an analytical reference standard for the quantification of 5-Azacitidine metabolites in pharmacokinetic and pharmacodynamic studies.
• Process Development: Used in scaling up and optimizing synthetic routes for the commercial production of related active pharmaceutical ingredients (APIs).

Basic Information

Product Name	5-Azacitidine 5'-Diphosphate
CAS No.	2226-73-5
Molecular Formula	C9H15N4O14P2
Molecular Weight	465.18 g/mol
Synonyms	5-Aza-2'-deoxycytidine 5'-diphosphate; 5-Aza-dC-DP; Ladakamycin 5'-diphosphate; 4-Amino-1-((2R,3S,5R)-3-hydroxy-5-((hydroxy((phosphonooxy)phosphoryl)oxy)methyl)tetrahydrofuran-2-yl)-1,3,5-triazin-2(1H)-one; 5-AzadC-DP; 5-Azacytidine 5'-diphosphate (common misnomer); Azacitidine diphosphate
EINECS	Contact for details

Quality Control

Our 5-Azacitidine 5'-Diphosphate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic (moisture-sensitive) nature, containers should be allowed to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.