Description

5'-Azacytidine 5'-Monophosphate is a biologically significant nucleotide analog, specifically the monophosphorylated form of the cytidine analog 5-azacytidine. This compound is a critical intermediate in the metabolic activation pathway, serving as a direct precursor for incorporation into nucleic acids. It is primarily utilized in advanced life science research and pharmaceutical development, particularly in the study of epigenetic mechanisms, DNA methylation, and as a tool compound for investigating nucleoside metabolism. The product is supplied under the CAS registry number 2226-72-4.

Application

• Epigenetics Research: As a key metabolite of 5-azacytidine, it is used to study DNA methyltransferase inhibition and gene expression regulation.
• Biochemical Synthesis: Serves as a building block or precursor in the enzymatic or chemical synthesis of modified oligonucleotides.
• Mechanistic Studies: Employed in pharmacokinetic and metabolic pathway research to understand the activation and action of nucleoside-based therapeutics.
• Pharmaceutical Reference Standard: Used as a high-purity analytical standard for quality control and method development in drug manufacturing.
• Cell Biology: Applied in cellular assays to investigate the effects of nucleotide pool alteration on replication and cell cycle progression.

Basic Information

Product Name	5'-Azacytidine 5'-Monophosphate
CAS No.	2226-72-4
Molecular Formula	C8H13N4O8P
Molecular Weight	324.18 g/mol
Synonyms	5-Azacytidine 5'-Monophosphate; 5-Aza-2'-deoxycytidine 5'-Monophosphate (common misnomer); Ladakamycin 5'-Monophosphate; Azacitidine 5'-Monophosphate; 5-AZCMP; 4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one 5'-Monophosphate; NSC 102816 (5'-Monophosphate)
EINECS	Contact for details

Quality Control

Our 5'-Azacytidine 5'-Monophosphate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) specifying batch-specific results is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (UV)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.