Description

Cucurbitacin I is a highly oxygenated tetracyclic triterpenoid belonging to the cucurbitacin family of natural products. This compound is of significant commercial and research interest due to its potent bioactivity, particularly its role as a selective inhibitor of the JAK/STAT signaling pathway. It serves as a critical reference standard and active pharmaceutical ingredient for organizations in the pharmaceutical, biotechnology, and academic research sectors focused on oncology, inflammation, and metabolic disease studies.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of herbal extracts, finished products, and biological samples in quality control laboratories.
• Biochemical Research Reagent: Employed as a selective JAK2/STAT3 inhibitor in cell-based assays and preclinical studies to investigate signaling pathways related to cancer proliferation and inflammation.
• Natural Product Isolation & Synthesis: Serves as a benchmark compound for the isolation, purification, and chemical synthesis of related cucurbitacin analogs.
• Dietary Supplement Analysis: Acts as a marker compound for the standardization and authentication of botanical supplements derived from Cucurbitaceae family plants.
• Academic & Contract Research: Utilized in university and CRO settings for fundamental research into the mechanisms of triterpenoid bioactivity and drug discovery projects.

Basic Information

Product Name	Cucurbitacin I
CAS No.	2222-07-3
Molecular Formula	C30H42O7
Molecular Weight	514.65 g/mol
Synonyms	Cucurbitacin I; Elatericin A; JSI-124; 23,24-Dihydrocucurbitacin F; (23R)-23,24-Dihydrocucurbitacin F; 3β,16α,20β,25-Tetrahydroxy-10α-cucurbita-5,23-diene-2,11,22-trione; NSC 521777
EINECS	Contact for details

Quality Control

Our Cucurbitacin I is produced and handled under strict quality management protocols. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. For long-term storage, consider storing at 2-8°C. Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.