Description

Benproperine is a synthetic, non-narcotic antitussive agent belonging to the piperidine derivative class, widely recognized for its effective cough-suppressing properties. Its primary value lies in its selective action on the cough center, providing relief without significant respiratory depression, making it a key active pharmaceutical ingredient (API) in modern cough formulations. This compound is essential for pharmaceutical manufacturers and research institutions developing and producing prescription and over-the-counter cough syrups, lozenges, and combination cold medications. We supply high-purity Benproperine to meet the stringent demands of global pharmaceutical production and advanced clinical research.

Application

• Pharmaceutical API: Primary use as the active ingredient in antitussive (cough suppressant) medications.
• Cough Syrup Formulations: Incorporated into liquid oral dosage forms for effective cough management.
• Tablet and Lozenge Production: Used in solid oral dosage forms for convenient and controlled delivery.
• Combination Cold Remedies: Formulated with other APIs like antihistamines or expectorants in multi-symptom relief products.
• Veterinary Pharmaceuticals: Applied in cough suppression formulations for animal health.
• Clinical Research: Serves as a reference standard and investigational compound in pharmacological studies.
• Generic Drug Manufacturing: Critical for producing cost-effective generic versions of branded antitussive drugs.

Basic Information

Product Name	Benproperine
CAS No.	2156-27-6
Molecular Formula	C21H27NO
Molecular Weight	309.45 g/mol
Synonyms	1-[1-Methyl-2-(2-methylphenoxy)ethyl]piperidine; Benproperine Phosphate (salt form); Blascorid; Pirexyl; Tussafug; Toplexil; Antitux; 1-Methyl-2-phenoxyethylpiperidine; α-Methyl-α-phenethyl-1-piperidineethanol
EINECS	218-452-7

Quality Control

Our Benproperine is manufactured under strict quality management systems to ensure it meets the high standards required for pharmaceutical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant pharmacopeial guidelines, and our quality commitment ensures reliable supply and batch-to-batch consistency for our global partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.