Description

2'-O-Methyladenosine is a chemically modified nucleoside where a methyl group is attached to the 2' oxygen of the ribose sugar. This modification is crucial for enhancing the stability and biological activity of oligonucleotides, making it a vital building block in advanced therapeutic and diagnostic research. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic institutions engaged in the development of antisense oligonucleotides, siRNA, and other nucleic acid-based therapeutics. Its consistent high purity is essential for ensuring the efficacy and reproducibility of downstream applications.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A key raw material for constructing oligonucleotides with improved nuclease resistance and binding affinity.
• siRNA and miRNA Research: Used to introduce stabilizing modifications into small interfering RNA and microRNA strands for gene silencing studies.
• Pharmaceutical Intermediates: Serves as a critical intermediate in the development of novel nucleoside-based antiviral and anticancer drugs.
• Diagnostic Probe Development: Incorporated into nucleic acid probes to enhance stability and specificity in diagnostic assays.
• Biochemical Research: Employed in enzymatic studies and as a substrate analog to investigate RNA metabolism and function.
• GMP Manufacturing: Supplied under controlled conditions for use in the Good Manufacturing Practice (GMP) production of therapeutic oligonucleotides.

Basic Information

Product Name	2'-O-Methyladenosine
CAS No.	2140-79-6
Molecular Formula	C11H15N5O4
Molecular Weight	281.27 g/mol
Synonyms	2'-O-Methyladenosine; 9-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-2-methyloxolan-2-yl]purin-6-amine; 2'-Methyladenosine; Adenosine, 2'-methyl-; 6-Amino-9-β-D-ribofuranosyl-9H-purine, 2'-methyl-; 2'-O-Methyl-A; 2'-OMe-A; N6-Adenosine, 2'-O-methyl-
EINECS	218-378-6

Quality Control

Every batch of 2'-O-Methyladenosine is subjected to rigorous analytical testing to ensure it meets the stringent purity requirements for nucleic acid research and pharmaceutical applications. Our standard quality protocol includes HPLC for purity assay, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, and we can support compliance with relevant pharmacopeial standards (e.g., USP monographs for related articles) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.