Description

2'-O-Methyluridine is a chemically modified nucleoside where a methyl group is attached to the 2' oxygen of the ribose sugar. This modification is crucial for enhancing the stability and biological activity of oligonucleotides, making it a valuable building block in advanced therapeutic and diagnostic applications. It is primarily sought after by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the development of antisense oligonucleotides, siRNA, and other RNA-based therapeutics.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A key monomer for creating nuclease-resistant RNA analogs to modulate gene expression.
• siRNA and miRNA Therapeutics: Used to introduce stability against degradation, improving the efficacy and duration of RNA interference agents.
• Diagnostic Probe Development: Incorporated into probes for in situ hybridization and other molecular diagnostics to enhance binding specificity and signal stability.
• Structural Biology Studies: Employed to investigate RNA structure, function, and protein-RNA interactions.
• Pharmaceutical Intermediate: Serves as a critical raw material in the synthesis of more complex nucleoside-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to nucleic acid metabolism.

Basic Information

Product Name	2'-O-Methyluridine
CAS No.	2140-76-3
Molecular Formula	C10H14N2O6
Molecular Weight	258.23 g/mol
Synonyms	2'-O-Methyluridine; 1-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]pyrimidine-2,4-dione; Uridine, 2'-methyl-; 2'-Methoxyuridine; 2'-O-Methyl-U; 2'-OMe-U; 2'-O-Me-uridine; 2'-Methyluridine
EINECS	218-378-9

Quality Control

Our 2'-O-Methyluridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.