Description

2'-o-Methylguanosine is a chemically modified nucleoside derivative where a methyl group is attached to the 2' oxygen of the ribose sugar. This specific modification is crucial for enhancing the stability and biological activity of oligonucleotides, making it a vital building block in advanced therapeutic and diagnostic research. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic institutions engaged in the development of next-generation nucleic acid-based therapies, including mRNA vaccines and antisense oligonucleotides.

Application

• Oligonucleotide Synthesis: A key phosphoramidite monomer for the solid-phase synthesis of chemically modified RNA and DNA strands.
• Therapeutic RNA Development: Used in the research and production of stabilized messenger RNA (mRNA) for vaccines and protein replacement therapies.
• Antisense & siRNA Applications: Incorporated into antisense oligonucleotides and small interfering RNA (siRNA) to improve nuclease resistance and target binding affinity.
• Diagnostic Probe Design: Serves as a component in the creation of high-specificity molecular probes and primers for diagnostic assays.
• Biochemical Research: Employed as a standard or substrate in enzymatic studies to investigate RNA metabolism, modification, and function.
• Pharmaceutical Intermediates: Acts as a critical intermediate in the synthesis of novel nucleoside-based antiviral or anticancer drug candidates.

Basic Information

Product Name	2'-o-Methylguanosine
CAS No.	2140-71-8
Molecular Formula	C11H15N5O5
Molecular Weight	297.27 g/mol
Synonyms	2'-O-Methylguanosine; 9-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-2-methyloxolan-2-yl]-1,9-dihydro-6H-purin-6-one; 2'-Methylguanosine; Guanosine, 2'-methyl-; O2'-Methylguanosine; 2'-OMe-Guo; 2'-O-Me-G
EINECS	218-374-5

Quality Control

Our 2'-o-Methylguanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and LC-MS for identity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.