Description

2-(Dimethylamino)Guanosine is a modified nucleoside derivative of guanosine, featuring a dimethylamino group at the 2-position of the purine base. This structural modification makes it a valuable intermediate and building block in advanced pharmaceutical research and development. It is primarily utilized by research institutions and manufacturers in the life sciences sector for applications in nucleoside chemistry, antiviral drug discovery, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to nucleoside metabolism and RNA function.
• Proteomics & Molecular Biology: Potential utility in the development of labeled probes or tools for studying nucleic acid interactions.
• Medicinal Chemistry: Serves as a critical scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	2-(Dimethylamino)Guanosine
CAS No.	2140-67-2
Molecular Formula	C₁₂H₁₈N₆O₅
Molecular Weight	326.31 g/mol
Synonyms	2-(Dimethylamino)guanosine; 2-(N,N-Dimethylamino)guanosine; 9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-(dimethylamino)-1H-purin-6-one; 2-Dimethylaminoguanosine; Guanosine, 2-(dimethylamino)-; N2,N2-Dimethylguanosine; 2-(Dimethylamino)-9-β-D-ribofuranosyl-9H-purin-6-ol
EINECS	Contact for details

Quality Control

Our 2-(Dimethylamino)Guanosine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.