Description

1-Methylguanosine is a modified nucleoside derivative of guanosine, playing a significant role in RNA structure and function. This high-purity biochemical is essential for advanced research and development in life sciences, where precise molecular tools are required. It is primarily utilized by pharmaceutical researchers, diagnostic developers, and academic institutions focused on nucleic acid chemistry, epigenetics, and metabolic pathway studies.

Application

• Biochemical Research: Used as a reference standard and substrate in studies of RNA modification, methylation processes, and nucleoside metabolism.
• Pharmaceutical Development: Serves as a key intermediate or starting material in the synthesis of novel antiviral or anticancer nucleoside analogs.
• Diagnostic Reagent Manufacturing: Incorporated into the production of specialized kits for detecting and quantifying modified nucleosides in biological samples.
• Enzymology Studies: Employed as a specific substrate for methyltransferase and other RNA-modifying enzymes to study catalytic mechanisms and inhibition.
• Life Science Reagents: A critical component in high-purity reagent mixes for molecular biology applications, including in vitro transcription and translation systems.

Basic Information

Product Name	1-Methylguanosine
CAS No.	2140-65-0
Molecular Formula	C11H15N5O5
Molecular Weight	297.27 g/mol
Synonyms	1-Methylguanosine; N1-Methylguanosine; Guanosine, 1-methyl-; 9-β-D-Ribofuranosyl-1-methylguanine; 1-Methyl-9-β-D-ribofuranosylguanine; m1G; 1-MeG; N(1)-Methylguanosine
EINECS	218-375-9

Quality Control

Our 1-Methylguanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept sealed in a desiccated environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.