Description

2',3'-o-Isopropylideneinosine is a key protected nucleoside derivative, serving as a vital intermediate in organic synthesis and pharmaceutical research. Its primary value lies in its role as a versatile building block for the preparation of modified nucleosides, nucleotides, and oligonucleotides, enabling advanced research in antiviral and anticancer drug discovery. This high-purity intermediate is essential for R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries who require reliable, high-quality starting materials for complex synthetic pathways.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used as a protected monomer for the solid-phase or solution-phase synthesis of modified RNA and DNA strands.
• Biochemical Research: Employed in enzymatic studies and as a substrate analog to investigate nucleotide metabolism and enzyme mechanisms.
• Prodrug Development: Facilitates the creation of prodrug forms of nucleoside-based therapeutics to improve bioavailability and targeting.
• Fine Chemical Synthesis: Serves as a chiral building block for the asymmetric synthesis of complex natural products and bioactive molecules.
• Academic & Industrial R&D: A standard reagent in laboratories focused on medicinal chemistry, chemical biology, and nucleic acid research.

Basic Information

Product Name	2',3'-o-Isopropylideneinosine
CAS No.	2140-11-6
Molecular Formula	C13H16N4O5
Molecular Weight	308.29 g/mol
Synonyms	9-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-3H-purin-6-one; 2',3'-O-Isopropylideneinosine; 2',3'-O-(1-Methylethylidene)inosine; Inosine, 2',3'-O-isopropylidene-; 2',3'-Isopropylideneinosine; 2',3'-O-Isopropylidene-9H-purin-6-ol; 6-Hydroxy-2',3'-O-isopropylidenepurine riboside
EINECS	Contact for details

Quality Control

Our 2',3'-o-Isopropylideneinosine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.