Description

9-Fluoro-11Beta-Hydroxy-16Alpha,17-(Isopropylidenedioxy)Pregna-1,4-Diene-3,20-Dione is a high-purity synthetic steroid derivative, serving as a critical advanced pharmaceutical intermediate. Its value lies in its precise molecular structure, which is engineered for targeted biological activity and serves as a key building block in complex synthesis pathways. This compound is essential for research and development laboratories and production facilities in the pharmaceutical industry, particularly those focused on developing novel corticosteroid or anti-inflammatory agents.

Application

• Pharmaceutical Intermediate: Primary use as a key synthetic precursor in the manufacture of potent topical and systemic corticosteroids.
• Active Pharmaceutical Ingredient (API) Synthesis: Integral building block for the synthesis of advanced steroid-based APIs with anti-inflammatory and immunosuppressive properties.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new therapeutic steroid analogs.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for steroid production under Good Manufacturing Practice (GMP) conditions.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical manufacturing.
• Biochemical Research: Tool compound for investigating steroid hormone receptor interactions and metabolic pathways in preclinical studies.

Basic Information

Product Name	9-Fluoro-11Beta-Hydroxy-16Alpha,17-(Isopropylidenedioxy)Pregna-1,4-Diene-3,20-Dione
CAS No.	2135-14-0
Molecular Formula	C24H31FO5
Molecular Weight	418.50 g/mol
Synonyms	9α-Fluoro-11β-hydroxy-16α,17α-isopropylidenedioxypregna-1,4-diene-3,20-dione; 9-Fluoro-11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione Cyclic 16,17-Acetal with Acetone; Fludrocortisone Acetonide Intermediate; 9α-Fluoro-16α,17α-(Isopropylidenedioxy)-11β-hydroxypregna-1,4-diene-3,20-dione; 2135-14-0; 9-Fluoro-11β-hydroxy-16α,17-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione
EINECS	Contact for details

Quality Control

Our 9-Fluoro-11Beta-Hydroxy-16Alpha,17-(Isopropylidenedioxy)Pregna-1,4-Diene-3,20-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting specifications suitable for pharmaceutical R&D and intermediate use. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.