Description

α-2'-Deoxythioguanosine is a modified nucleoside analog where the oxygen atom in the 2'-deoxyribose sugar is replaced by sulfur, creating a thioglycosidic bond. This structural modification is crucial for its role as a key intermediate in the synthesis of oligonucleotides and nucleotide-based therapeutics, offering enhanced stability and unique biochemical properties. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel antiviral agents, anticancer drugs, and advanced molecular biology tools.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of modified oligonucleotides and nucleotide analogs used in drug discovery.
• Antiviral & Anticancer Research: Serves as a precursor in the development of nucleoside reverse transcriptase inhibitors (NRTIs) and other chemotherapeutic agents targeting DNA/RNA synthesis.
• Molecular Biology & Biochemistry: Used in the study of enzyme mechanisms, particularly those involving glycosyltransferases and nucleoside-metabolizing enzymes.
• Proteomics & Diagnostic Development: Employed in the creation of labeled probes and substrates for diagnostic assays and high-throughput screening.
• Academic & Industrial R&D: Essential for fundamental research in medicinal chemistry, chemical biology, and nucleic acid chemistry.

Basic Information

Product Name	α-2'-Deoxythioguanosine
CAS No.	2133-81-5
Molecular Formula	C₁₀H₁₃N₅O₃S
Molecular Weight	283.31 g/mol
Synonyms	2'-Deoxy-6-thioguanosine; 6-Thio-2'-deoxyguanosine; 2'-Deoxy-6-thioguanine riboside; 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-sulfanyl-1H-purin-2-one; 6-Thio-dG; α-2'-Deoxythioguanosine; Thioguanine deoxyriboside
EINECS	Contact for details

Quality Control

Our α-2'-Deoxythioguanosine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and moisture content. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.