Description

8-Azaguanosine is a purine nucleoside analog where a nitrogen atom replaces the carbon at the 8-position of the guanosine structure. This compound is a key intermediate and research chemical in the development of novel antiviral and anticancer agents, offering a unique scaffold for probing nucleic acid metabolism and enzyme function. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on nucleoside chemistry and medicinal chemistry.

Application

• Pharmaceutical Research & Development: Serves as a crucial building block for synthesizing novel nucleoside analogs with potential antiviral and antitumor activities.
• Biochemical Studies: Used as a substrate or inhibitor to study the mechanisms of purine-metabolizing enzymes like nucleoside phosphorylases and kinases.
• Antiviral Agent Development: Investigated for its potential activity against various viral families by interfering with viral RNA/DNA synthesis.
• Oncology Research: Explored for its antiproliferative effects and as a precursor for chemotherapeutic prodrugs targeting specific cancer pathways.
• Nucleic Acid Chemistry: Employed in the synthesis of modified oligonucleotides for structural, biophysical, and diagnostic applications.
• Enzyme Inhibition Assays: Acts as a reference compound in high-throughput screening for identifying new enzyme inhibitors.

Basic Information

Product Name	8-Azaguanosine
CAS No.	2133-80-4
Molecular Formula	C9H12N6O5
Molecular Weight	284.23 g/mol
Synonyms	8-Aza-guanosine; Guanosine, 8-aza-; 8-Azaguanylic acid riboside; NSC 20164; 8-Azaguanine riboside; β-D-Ribofuranoside, 8-azaguanine-9; 9-β-D-Ribofuranosyl-8-azaguanine; 8-Aza-Guo
EINECS	218-365-5

Quality Control

Our 8-Azaguanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and protected from light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.