Description

4-Carboxyphenyl Isothiocyanate is a versatile bifunctional organic building block that combines a reactive isothiocyanate group with a carboxylic acid moiety. This unique structure makes it a critical intermediate for the synthesis of complex molecules, particularly in pharmaceutical research and advanced material science. It is essential for chemists and manufacturers in the life sciences, agrochemical, and specialty chemical sectors who require high-purity intermediates for coupling reactions and derivatization.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting specific biological pathways.
• Bioconjugation & Labeling Reagent: Used to modify proteins, peptides, and other biomolecules via reaction with amine groups, enabling the creation of fluorescent probes or drug conjugates.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and plant growth regulators.
• Polymer & Material Science: Monomer for creating functional polymers, coatings, and resins with tailored properties.
• Chemical Research & Development: A valuable tool in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Derivatization Agent: Used in analytical chemistry to enhance the detection or separation of amines and amino acids in chromatographic methods.

Basic Information

Product Name	4-Carboxyphenyl Isothiocyanate
CAS No.	2131-62-6
Molecular Formula	C8H5NO2S
Molecular Weight	179.20 g/mol
Synonyms	4-Isothiocyanatobenzoic Acid; p-Carboxyphenyl Isothiocyanate; p-Isothiocyanatobenzoic Acid; Benzoic acid, 4-isothiocyanato-; 4-Carboxybenzenisothiocyanate; 4-Carboxy Phenyl Isothiocyanate; 4-CPITC; 4-Isothiocyanato-benzoic acid
EINECS	218-356-4

Quality Control

Our 4-Carboxyphenyl Isothiocyanate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	158 - 162 °C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.