Description

4-Nitrophenyl Isothiocyanate is a versatile organic building block characterized by its reactive isothiocyanate and nitro functional groups. This compound is essential for the synthesis of thiourea derivatives and serves as a key reagent in heterocyclic chemistry. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and material science sectors for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of thiourea-based drug candidates, including potential enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used to create novel pesticides and herbicides by incorporating the thiourea moiety into active molecules.
• Peptide Chemistry & Bioconjugation: Acts as a coupling agent for labeling proteins, peptides, and other biomolecules via reaction with amine groups.
• Material Science Research: Employed in the development of functional polymers, sensors, and advanced organic materials.
• Chemical Derivatization Agent: Used in analytical chemistry to derivative amines and amino acids for detection and separation purposes (e.g., in HPLC).
• Academic & Industrial R&D: Serves as a fundamental reagent for exploring new organic reactions and synthesizing complex heterocyclic compounds.

Basic Information

Product Name	4-Nitrophenyl Isothiocyanate
CAS No.	2131-61-5
Molecular Formula	C7H4N2O2S
Molecular Weight	180.18 g/mol
Synonyms	p-Nitrophenyl Isothiocyanate; 1-Isothiocyanato-4-nitrobenzene; 4-Nitrobenzenisothiocyanate; 4-Nitrophenyl Mustard Oil; (4-Nitrophenyl)carbamothioic Thioanhydride; NSC 401579; 4-Nitro-phenylisothiocyanate
EINECS	218-366-7

Quality Control

Our 4-Nitrophenyl Isothiocyanate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC purity, identity confirmation (IR, NMR), and impurity profiling. A Certificate of Analysis (COA) is supplied with each shipment, detailing all relevant specifications. Our quality management system supports compliance with cGMP and ISO standards for research and industrial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials such as strong bases, amines, and alcohols. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	115 - 120 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.