Description

4-Hydroxyphenylisothiocyanate is a versatile aromatic isothiocyanate derivative that serves as a critical building block in organic synthesis. Its bifunctional nature, featuring both a reactive isothiocyanate group and a phenolic hydroxyl group, makes it a valuable intermediate for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for the synthesis of heterocycles, dyes, and biologically active compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, including kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel pesticides, herbicides, and plant growth regulators.
• Peptide & Protein Modification: Acts as a coupling agent or labeling reagent for modifying amino groups in peptides and proteins.
• Dye & Pigment Manufacturing: Serves as an intermediate for producing azo dyes and other high-performance colorants.
• Polymer Chemistry: Employed as a monomer or cross-linking agent for creating specialty polymers with specific functional properties.
• Research & Development: A valuable reagent in academic and industrial R&D labs for exploring new synthetic pathways and material science applications.

Basic Information

Product Name	4-Hydroxyphenylisothiocyanate
CAS No.	2131-60-4
Molecular Formula	C7H5NOS
Molecular Weight	151.19 g/mol
Synonyms	4-Isothiocyanatophenol; p-Hydroxyphenyl isothiocyanate; 1-Hydroxy-4-isothiocyanatobenzene; Phenol, 4-isothiocyanato-; Isothiocyanic acid, 4-hydroxyphenyl ester; PHIT; p-Hydroxy phenylisothiocyanate
EINECS	218-361-6

Quality Control

Our 4-Hydroxyphenylisothiocyanate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) documenting all critical parameters are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.