Description

8-Methylthioguanosine is a chemically modified nucleoside analog of guanosine, where a methylthio group replaces the oxygen at the 8-position. This structural modification is critical for its role as a key intermediate and research tool in the development of novel pharmaceuticals and biochemical probes. It is primarily utilized by research institutions and pharmaceutical companies engaged in antiviral drug discovery, nucleic acid chemistry, and metabolic pathway studies. The compound's unique properties make it valuable for investigating RNA function and designing targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to purine metabolism and RNA modification.
• Proteomics & Metabolomics: Acts as a standard or tracer in mass spectrometry-based studies of cellular nucleotide pools.
• Antiviral Agent Development: Investigated for its potential activity against RNA viruses due to its ability to incorporate into viral nucleic acids.
• Molecular Biology: Employed in the study of RNA structure, function, and post-transcriptional modifications.
• Chemical Biology Tool: Utilized to probe biological systems and develop novel diagnostic assays.

Basic Information

Product Name	8-Methylthioguanosine
CAS No.	2104-66-7
Molecular Formula	C11H15N5O5S
Molecular Weight	329.33 g/mol
Synonyms	8-(Methylthio)guanosine; 8-Methylmercaptoguanosine; 8-MTG; 8-S-Methylguanosine; Guanosine, 8-(methylthio)-; 8-Methylthio-guanosine; 8-(Methylsulfanyl)guanosine; NSC 401005
EINECS	218-267-3

Quality Control

Our 8-Methylthioguanosine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and IR for structural confirmation, and stringent controls for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.