Description

1-Adamantanecarbonyl Chloride is a versatile and highly reactive adamantane derivative, serving as a crucial building block in advanced organic synthesis. Its rigid, cage-like adamantane core imparts unique stability and lipophilicity to target molecules, making it invaluable for creating compounds with enhanced properties. This high-purity intermediate is primarily sought by the pharmaceutical, agrochemical, and material science industries for research and development, as well as process-scale manufacturing.

Application

• Pharmaceutical Intermediate: Key precursor for synthesizing adamantane-based active pharmaceutical ingredients (APIs), including antiviral and neurological disorder treatments.
• Agrochemical Synthesis: Used to create novel pesticides and herbicides with improved stability and efficacy due to the adamantane moiety.
• Polymer & Material Science: Acts as a monomer or cross-linking agent to develop high-performance polymers, resins, and advanced materials with superior thermal and chemical resistance.
• Ligand & Catalyst Development: Employed in the preparation of specialized ligands and organocatalysts for asymmetric synthesis and other catalytic processes.
• Peptide & Protein Modification: Useful as an acylating agent for modifying peptides and proteins to enhance their metabolic stability or alter their biological activity.
• Dendrimer & Nanomaterial Construction: Serves as a core or branching unit in the synthesis of complex dendritic structures and functional nanomaterials.

Basic Information

Product Name	1-Adamantanecarbonyl Chloride
CAS No.	2094-72-6
Molecular Formula	C11H15ClO
Molecular Weight	198.69 g/mol
Synonyms	Adamantane-1-carbonyl chloride; 1-Adamantoyl chloride; 1-Carboxyadamantane chloride; Tricyclo[3.3.1.13,7]decane-1-carbonyl chloride; AdCOCl; Adamantylcarbonyl chloride; 1-Adamantanecarboxylic acid chloride
EINECS	218-245-2

Quality Control

Our 1-Adamantanecarbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and identity. We provide detailed Certificates of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and materials for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from moisture, strong bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	142 - 147 °C
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.