Description

5-Fluorocytosine CAS NO 2022-85-7 is a fluorinated pyrimidine analog, a critical synthetic intermediate and active pharmaceutical ingredient (API) in the pharmaceutical industry. Its primary value lies in its role as a key building block for synthesizing more complex fluorinated nucleosides and anticancer agents, offering a strategic entry point for advanced drug development. This compound is essential for manufacturers and research institutions focused on oncology research, antiviral drug discovery, and the production of high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of fluorinated anticancer drugs (e.g., capecitabine, gemcitabine analogs) and antiviral agents.
• Antifungal Agent: Used as the active pharmaceutical ingredient (API) in the antifungal medication flucytosine, primarily for treating systemic fungal infections like cryptococcosis and candidiasis.
• Biochemical Research: Employed in molecular biology and oncology research to study cell proliferation, nucleic acid metabolism, and mechanisms of antifungal action.
• Nucleoside Synthesis: Serves as a fundamental building block for creating modified nucleosides and nucleotides used in diagnostic assays and therapeutic oligonucleotides.
• Agrochemical Development: Investigated as an intermediate for developing novel, targeted pesticides and herbicides due to its specific biochemical activity.

Basic Information

Product Name	5-Fluorocytosine
CAS No.	2022-85-7
Molecular Formula	C4H4FN3O
Molecular Weight	129.09 g/mol
Synonyms	Flucytosine; 4-Amino-5-fluoro-2(1H)-pyrimidinone; 5-FC; 5-Fluorocytosin; Ancobon; Alcobon; 5-Fluoro-4-aminopyrimidin-2(1H)-one; 2-Hydroxy-5-fluoropyrimidin-4-amine
EINECS	217-968-7

Quality Control

Our 5-Fluorocytosine is manufactured under strict quality management systems. We offer grades suitable for pharmaceutical and research applications, with specifications that can meet relevant pharmacopoeial standards (e.g., USP, EP). Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% - 102.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.