Description

3-(Trifluoromethyl)Phenylacetyl Chloride is a versatile and reactive organofluorine building block essential for advanced chemical synthesis. Its trifluoromethylphenyl moiety and acid chloride functionality make it a critical intermediate for introducing specific structural motifs with enhanced properties. This compound is primarily sought after by research and development chemists and process engineers in the pharmaceutical and agrochemical industries. It enables the efficient synthesis of complex molecules where the trifluoromethyl group is desired for its metabolic stability and lipophilicity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a trifluoromethylphenyl group to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated compounds used in electronic displays and organic light-emitting diodes due to improved electronic properties.
• Polymer Modification: Employed to introduce fluorinated side chains into polymers, enhancing their chemical resistance, thermal stability, and surface properties.
• Peptide & Protein Research: Acts as an acylating agent for modifying amino acids or peptides to study structure-activity relationships.
• Dye & Pigment Manufacturing: Intermediate in creating specialized fluorinated dyes and pigments with unique color fastness and solubility profiles.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for constructing biaryl systems.
• Custom Synthesis & Contract Manufacturing: Supplied to fine chemical companies for bespoke synthesis projects and scale-up development.

Basic Information

Product Name	3-(Trifluoromethyl)Phenylacetyl Chloride
CAS No.	2003-14-7
Molecular Formula	C9H6ClF3O
Molecular Weight	222.59 g/mol
Synonyms	3-(Trifluoromethyl)benzeneacetyl chloride; 2-[3-(Trifluoromethyl)phenyl]acetyl chloride; m-(Trifluoromethyl)phenylacetyl chloride; 3-(Trifluoromethyl)phenacetyl chloride; α-Chloro-3-(trifluoromethyl)acetophenone; (3-Trifluoromethylphenyl)acetyl chloride; 2-(3-Trifluoromethylphenyl)acetyl chloride; 2003-14-7
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethyl)Phenylacetyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specification parameters. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep away from strong bases, oxidizing agents, and sources of ignition. Store in original container or one of equivalent chemical compatibility.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.