Description

Carboxy-Peg4-Phosphonic Acid Ethyl Ester is a high-purity, functionalized PEG linker featuring a carboxylic acid and a phosphonic acid ethyl ester group, connected by a tetraethylene glycol spacer. This bifunctional structure is critical for creating stable, hydrophilic, and bio-compatible conjugates in advanced pharmaceutical and biotechnological research. It is primarily utilized by researchers and process development scientists in the fields of bioconjugation, prodrug development, and the synthesis of novel drug delivery systems such as antibody-drug conjugates (ADCs) and targeted therapeutics.

Application

• Bioconjugation Reagent: Serves as a versatile heterobifunctional crosslinker for coupling biomolecules (e.g., antibodies, peptides, proteins) to drugs, dyes, or solid surfaces.
• ADC (Antibody-Drug Conjugate) Development: Enables the construction of stable, cleavable, or non-cleavable linkers between a monoclonal antibody and a cytotoxic payload, improving therapeutic index.
• Prodrug Synthesis: Used to design water-soluble prodrugs by attaching the carboxylic acid end to an active pharmaceutical ingredient (API), with the phosphonate ester acting as a tunable moiety.
• Surface Functionalization: Modifies nanoparticles, quantum dots, or diagnostic assay platforms to introduce carboxylic acid groups for further coupling, enhancing biocompatibility and targeting.
• Polymer Chemistry: Acts as a functional monomer or chain extender in the synthesis of specialized, biodegradable polymers for medical applications.
• Chemical Biology Probes: Facilitates the creation of tools for studying enzyme activity, protein-protein interactions, and cellular targeting mechanisms.

Basic Information

Product Name	Carboxy-Peg4-Phosphonic Acid Ethyl Ester
CAS No.	1964503-39-6
Molecular Formula	C14H29O11P
Molecular Weight	404.35 g/mol
Synonyms	15-Carboxy-4,7,10,13-tetraoxapentadecane-1-phosphonic acid ethyl ester; 2-[2-[2-[2-[2-(Diethoxyphosphoryl)ethoxy]ethoxy]ethoxy]ethoxy]acetic acid; Acetic acid, 2-[2-[2-[2-[2-(diethoxyphosphoryl)ethoxy]ethoxy]ethoxy]ethoxy]-; Carboxy-PEG4-phosphonate ethyl ester; HOOC-PEG4-P(O)(OEt)2; (Ethoxyphosphoryl) PEG4 carboxylic acid; PEG4-acid-phosphonate ethyl ester; 4-Arm PEG crosslinker acid/phosphonate ester
EINECS	Contact for details

Quality Control

Every batch of Carboxy-Peg4-Phosphonic Acid Ethyl Ester is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) that include data from NMR (1H, 13C, 31P), HPLC, and mass spectrometry. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring suitability for research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.