Description

Ulixertinib Hydrochloride is a highly potent and selective small-molecule inhibitor of extracellular signal-regulated kinase (ERK) 1 and 2. This compound is crucial for targeted cancer research and therapeutic development, specifically for tumors driven by MAPK pathway mutations. It is primarily utilized by pharmaceutical R&D departments, contract research organizations (CROs), and academic institutions focused on oncology. The product is supplied under strict quality control to ensure reliable and reproducible results in critical research applications.

Application

• Oncology Research: A key tool compound for investigating the role of ERK signaling in various cancer cell lines and tumor models.
• Drug Discovery & Development: Used as a reference standard or active pharmaceutical ingredient (API) in preclinical studies for novel cancer therapeutics.
• Biochemical Assays: Employed in high-throughput screening and in vitro kinase assays to study ERK inhibition and downstream effects.
• Mechanistic Studies: Facilitates research into resistance mechanisms to upstream BRAF and MEK inhibitors in melanoma and other cancers.
• Pharmacology Research: Used to evaluate pharmacokinetics, pharmacodynamics, and efficacy in animal models of cancer.
• Academic Research: Supports basic science investigations into the MAPK/ERK pathway's role in cell proliferation, survival, and differentiation.

Basic Information

Product Name	Ulixertinib Hydrochloride
CAS No.	1956366-10-1
Molecular Formula	C22H23ClFN5O3 • HCl
Molecular Weight	504.36 g/mol (for hydrochloride salt)
Synonyms	BVD-523 Hydrochloride; VRT752271 Hydrochloride; (S)-1-(3-(2-Chloro-5-fluorophenyl)-1H-pyrazolo[3,4-b]pyridin-4-yloxy)-3-piperidin-1-yl-propan-2-ol Hydrochloride; ERK Inhibitor Ulixertinib HCl; Ulixertinib HCl; Ulixertinib Hydrochloride Salt; BVD 523 HCl
EINECS	Contact for details

Quality Control

Our Ulixertinib Hydrochloride is manufactured and tested under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets high-purity standards suitable for research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm
Assay (on anhydrous basis)	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.