Description

1-((tert-Butyldiphenylsilyl)Oxy)-3-Chloropropan-2-One is a high-value, organosilicon-protected chloroketone building block used in advanced organic synthesis. This compound is critical for researchers and process chemists requiring precise control over molecular architecture, particularly in the construction of complex, multi-functional intermediates. It is primarily utilized in the pharmaceutical, agrochemical, and specialty chemical industries for the development of active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules requiring protected hydroxyl or carbonyl functionalities.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the chloroketone moiety introduces reactive handles for further derivatization.
• Peptide Mimetics & Bioconjugation: Serves as a versatile linker or spacer in the design of peptide analogs and for the site-specific modification of biomolecules.
• Material Science Research: Employed in the development of novel polymers, dendrimers, and functionalized surfaces where the tert-butyldiphenylsilyl (TBDPS) group provides steric protection.
• Cross-Coupling Reactions: Acts as a substrate in various metal-catalyzed reactions, such as Suzuki or Heck couplings, after further functionalization.
• Academic & R&D Laboratories: Essential reagent for methodological development in organic chemistry and for exploring new synthetic pathways.

Basic Information

Item	Details
Product Name	1-((tert-Butyldiphenylsilyl)Oxy)-3-Chloropropan-2-One
CAS No.	1956332-66-3
Molecular Formula	C19H23ClO2Si
Molecular Weight	346.92 g/mol
Synonyms	3-Chloro-1-((tert-butyldiphenylsilyl)oxy)propan-2-one; 1-[(tert-Butyldiphenylsilyl)oxy]-3-chloropropan-2-one; 3-Chloro-2-oxopropyl tert-butyl(diphenyl)silane; TBDPS-protected 3-chloro-2-hydroxyacetone; tert-Butyl(chloroacetoxymethyl)diphenylsilane; Chloroacetone TBDPS ether; (3-Chloro-2-oxopropoxy)(tert-butyl)diphenylsilane
EINECS	Contact for details

Quality Control

Our production of 1-((tert-Butyldiphenylsilyl)Oxy)-3-Chloropropan-2-One adheres to stringent in-process controls to ensure batch-to-batch consistency and high chemical purity. All materials are fully characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for prolonged storage to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.