Description

Giredestrant CAS NO 1953133-47-5 is a potent and selective oral estrogen receptor degrader (SERD) designed for targeted cancer therapy. This compound is critical for advancing research and development in oncology, specifically for the treatment of hormone receptor-positive (HR+) breast cancer. It is an essential active pharmaceutical ingredient (API) and research chemical for pharmaceutical manufacturers, biotechnology firms, and academic research institutions focused on developing next-generation endocrine therapies.

Application

• Primary Active Pharmaceutical Ingredient (API) in the formulation of oral anti-cancer drugs.
• Key research compound for preclinical and clinical studies targeting estrogen receptor-positive (ER+) breast cancer.
• Development of novel SERD (Selective Estrogen Receptor Degrader) therapies for advanced or metastatic breast cancer.
• Biochemical research to investigate mechanisms of estrogen receptor degradation and resistance pathways.
• Use as a reference standard in analytical laboratories for quality control and method development.
• Investigational new drug (IND) enabling studies and pharmacology research.

Basic Information

Product Name	Giredestrant
CAS No.	1953133-47-5
Molecular Formula	C26H28F3N5O3S
Molecular Weight	547.59 g/mol
Synonyms	GDC-9545; RG6171; (S)-3-(4-((2-(2-Chloro-4-fluorophenyl)-1,1-difluoro-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-2,6-dimethylphenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazole; Giredestrant (USAN); Giredestrantum; LY3484356; Giredestrant (GDC-9545)
EINECS	Contact for details

Quality Control

Our Giredestrant is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and potency meet the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed HPLC chromatograms and impurity profiles are provided for every shipment, supporting regulatory submissions and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.