Description

Eliapixant CAS NO 1948229-21-7 is a potent and selective P2X3 receptor antagonist, representing a significant advancement in the field of small molecule drug discovery. This compound is of critical importance for its targeted mechanism of action, offering a promising therapeutic approach for conditions involving chronic cough and neuropathic pain. It is primarily needed by pharmaceutical research and development organizations, contract research organizations (CROs), and academic institutions engaged in neuroscience, respiratory pharmacology, and novel analgesic development.

Application

• Pharmaceutical Reference Standard: Serves as a primary standard for analytical method development, validation, and quality control in drug manufacturing.
• Clinical Research Material: Used as a key active pharmaceutical ingredient (API) intermediate or impurity standard in clinical trial material synthesis and characterization.
• Mechanistic & Target Validation Studies: Employed in in vitro and in vivo research to study P2X3 receptor function and validate its role in disease pathways.
• Chronic Cough Research: A critical tool for investigating novel treatments for refractory or unexplained chronic cough.
• Neuropathic Pain Research: Used in preclinical models to explore new therapeutic avenues for pain management.
• Biochemical Assay Development: Utilized as a ligand in high-throughput screening (HTS) and binding assays to discover new chemical entities.

Basic Information

Product Name	Eliapixant
CAS No.	1948229-21-7
Molecular Formula	C₂₀H₂₀F₃N₅O₃
Molecular Weight	435.40 g/mol
Synonyms	BAY 1817080; Eliapixant (BAY-1817080); (1R,2S)-2-[[6-Amino-5-(2,4,5-trifluorophenoxy)pyrimidin-4-yl]amino]cyclohexane-1-carboxamide; BAY1817080; BAY 1817080; (1R,2S)-2-({6-Amino-5-[(2,4,5-trifluorophenoxy)pyrimidin-4-yl]amino}cyclohexanecarboxamide
EINECS	Contact for details

Quality Control

Our Eliapixant is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (NMR, IR, MS), purity determination by HPLC, and control of specified impurities. A Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). The product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.