Description

Tepotinib Hydrochloride Hydrate is a highly potent and selective small-molecule inhibitor targeting the mesenchymal-epithelial transition (MET) tyrosine kinase receptor. This compound is of significant value in pharmaceutical research and development, particularly for its role in targeting cancers driven by MET gene alterations, such as non-small cell lung cancer (NSCLC). It is primarily needed by pharmaceutical companies, biotechnology research firms, and academic institutions engaged in oncology drug discovery, preclinical studies, and the development of targeted cancer therapies.

Application

• Primary active pharmaceutical ingredient (API) in the formulation of targeted cancer therapeutics.
• Critical reference standard for analytical method development and validation in quality control laboratories.
• Key intermediate in advanced research on MET signaling pathways and resistance mechanisms.
• Essential biochemical tool for in vitro and in vivo pharmacological studies and efficacy testing.
• Used in the development and calibration of diagnostic assays for MET amplification and exon 14 skipping mutations.
• Vital component in combination therapy research to overcome drug resistance in oncology.

Basic Information

Product Name	Tepotinib Hydrochloride Hydrate
CAS No.	1946826-82-9
Molecular Formula	C29H28N6O2 • HCl • xH2O
Molecular Weight	532.99 (Anhydrous free base)
Synonyms	Tepotinib HCl Hydrate; MSC 2156119J; EMD 1214063; 3-[1-[[3,5-Bis(trifluoromethyl)phenyl]methyl]-6-(4-fluoro-2-pyridinyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-1,2,4-oxadiazol-5-amine Hydrochloride Hydrate; Tepmetko (brand name form); MET Inhibitor Tepotinib Hydrochloride; Tepotinib (free base)
EINECS	Contact for details

Quality Control

Our Tepotinib Hydrochloride Hydrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR, MS), and stringent control of residual solvents and impurities to ensure it meets high-grade standards suitable for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. Due to its hygroscopic nature, the container must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.