Description

1-Methylpseudouridine-5'-Triphosphate Sodium Salt is a chemically modified nucleotide triphosphate analog essential for advanced mRNA synthesis. This compound is critical for enhancing the stability and translational efficiency of mRNA therapeutics and vaccines by reducing immunogenicity. It is a key raw material for pharmaceutical R&D and manufacturing, particularly for developers of next-generation mRNA-based treatments and vaccines.

Application

• mRNA Vaccine & Therapeutic Manufacturing: As a modified UTP analog for in vitro transcription (IVT) to produce mRNA with improved properties.
• Research & Development: For studying mRNA structure, function, and stability in academic and biopharmaceutical research settings.
• Therapeutic Protein Production: In the synthesis of mRNA encoding therapeutic proteins for cell reprogramming or protein replacement therapies.
• Diagnostic Probe Development: Used in the creation of stabilized mRNA probes for sensitive detection and diagnostic assays.
• CRISPR & Gene Editing: For synthesizing guide RNAs (gRNAs) with enhanced nuclease resistance and efficacy.
• Cell & Gene Therapy: A critical component in the production of mRNA for ex vivo cell engineering and in vivo gene expression.

Basic Information

Product Name	1-Methylpseudouridine-5'-Triphosphate Sodium Salt
CAS No.	1931922-77-8
Molecular Formula	C11H15N2O14P3Na3 (or similar, based on salt form)
Molecular Weight	Contact for details
Synonyms	1-Methyl-ψ-5'-Triphosphate Sodium Salt; N1-Methylpseudouridine-5'-triphosphate trisodium salt; m1ψTP Na Salt; 1-Methylpseudouridine triphosphate; 5'-Triphosphoric acid, P1-(1-methyl-5-β-D-ribofuranosylpseudouridine-5') ester, trisodium salt; Modified Nucleotide Triphosphate; 1-Methyl-ψ UTP
EINECS	Contact for details

Quality Control

Our 1-Methylpseudouridine-5'-Triphosphate Sodium Salt is manufactured under strict quality systems suitable for pharmaceutical R&D. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive biological applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Aliquot to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥95%
Assay (UV)	≥90%
Water Content (KF)	≤5%
Endotoxin	<1.0 EU/mg
Solubility	Soluble in water, buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.