Description

Loxo-101 Hcl Salt is a high-purity, small molecule pharmaceutical intermediate and reference standard. This compound is critical for research and development in targeted cancer therapies, particularly in the field of kinase inhibition. It is primarily utilized by pharmaceutical companies, biotechnology research firms, and academic institutions engaged in oncology drug discovery and analytical method development.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced investigational oncology drugs.
• Reference Standard: Used for analytical method development, validation, and quality control (QC/QA) in pharmaceutical manufacturing.
• Biochemical Research: Employed in in vitro studies to investigate kinase inhibition pathways and mechanisms of action.
• Preclinical Development: Utilized in formulation studies and pharmacokinetic/pharmacodynamic (PK/PD) research for novel therapeutic candidates.
• Active Pharmaceutical Ingredient (API) Development: Supports process chemistry and scale-up activities for new drug applications (NDA).

Basic Information

Product Name	Loxo-101 Hcl Salt
CAS No.	1919868-83-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	LOXO-101 hydrochloride; Larotrectinib hydrochloride; ARRY-470 hydrochloride; Vitrakvi intermediate; NTRK inhibitor intermediate; (3S)-N-[5-[(2R)-2-(2,5-difluorophenyl)-1-pyrrolidinyl]pyrazolo[1,5-a]pyrimidin-3-yl]-3-hydroxy-1-pyrrolidinecarboxamide hydrochloride
EINECS	Contact for details

Quality Control

Our Loxo-101 Hcl Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.