Description

Lazertinib is a highly potent, brain-penetrant, and selective third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. It is a critical pharmaceutical intermediate and active pharmaceutical ingredient (API) primarily developed for the targeted treatment of non-small cell lung cancer (NSCLC), specifically in patients with EGFR T790M mutations. This compound is essential for pharmaceutical manufacturers and advanced research institutions engaged in oncology drug development and precision medicine.

Application

• Primary use as an Active Pharmaceutical Ingredient (API) in the formulation of targeted anti-cancer therapeutics.
• Key component in oncology research for studying EGFR mutation-driven cancers and drug resistance mechanisms.
• Critical intermediate in the synthesis and development of novel EGFR tyrosine kinase inhibitors.
• Used in preclinical and clinical studies to evaluate efficacy against NSCLC and other solid tumors.
• Reference standard for analytical method development and quality control in pharmaceutical manufacturing.
• Tool compound for investigating blood-brain barrier penetration and central nervous system (CNS) efficacy of oncology drugs.

Basic Information

Product Name	Lazertinib
CAS No.	1903008-80-9
Molecular Formula	C23H22FN5O2
Molecular Weight	419.45 g/mol
Synonyms	YH25448; GNS-1480; Lazertinib (YH25448); N-(3-((2-(2-Fluoro-4-((2-(methylamino)pyrimidin-5-yl)oxy)phenyl)amino)-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)methyl)phenyl)acrylamide; (E)-N-(3-((2-((2-Fluoro-4-((2-(methylamino)pyrimidin-5-yl)oxy)phenyl)amino)-5-methyl-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)methyl)phenyl)acrylamide
EINECS	Contact for details

Quality Control

Our Lazertinib is manufactured under strict quality management systems to ensure it meets the high-purity standards required for pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity, purity, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, and we support compliance with cGMP and ICH Q7 guidelines for active pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C (59-77°F), in a dry environment. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.