Description

Molibresib Besylate is a potent and selective small molecule inhibitor of the bromodomain and extra-terminal (BET) family of proteins. This compound is a critical research tool and pharmaceutical intermediate for developing novel oncology therapeutics. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and academic research institutions focused on cancer biology and epigenetic drug discovery. The besylate salt form enhances its stability and suitability for formulation development.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) in preclinical and clinical studies for BET inhibitor programs.
• Oncology Drug Discovery: Used as a potent tool compound to investigate the role of BET proteins in various cancers, including hematological malignancies and solid tumors.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) and in vitro assays to study protein-protein interactions and epigenetic modulation.
• Mechanism of Action Studies: Facilitates research into downstream signaling pathways and gene expression changes mediated by BET protein inhibition.
• Combination Therapy Research: Investigated in conjunction with other therapeutic agents to explore synergistic anti-cancer effects.
• API for Formulation: Used in the development of various dosage forms during the drug development process.

Basic Information

Product Name	Molibresib Besylate
CAS No.	1895049-20-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	GSK525762A; I-BET762; I-BET-762; Molibresib benzenesulfonate; (R)-N-(4-(4-Chlorophenyl)-5,6-dihydro-7H-cyclopenta[b]pyridin-7-yl)-2-methyl-2H-pyrazole-3-carboxamide benzenesulfonate; BET Inhibitor GSK525762
EINECS	Contact for details

Quality Control

Our Molibresib Besylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR, MS), and residual solvent analysis to ensure compliance with ICH guidelines. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee traceability and consistency for your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic nature, the container must be sealed under dry conditions and allowed to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH limits
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.