Description

5-Azidomethyl-2',3',5'-Tri-o-Benzoyl Uridine is a key protected nucleoside derivative, specifically designed for advanced oligonucleotide synthesis and bioconjugation applications. Its core value lies in the azidomethyl functional group, which serves as a versatile handle for efficient, bioorthogonal "click chemistry" reactions, such as the copper-catalyzed azide-alkyne cycloaddition (CuAAC). This compound is essential for researchers and manufacturers in the fields of pharmaceutical development, diagnostic probe synthesis, and chemical biology, where precise modification of nucleic acids is required.

Application

• Oligonucleotide Synthesis: Acts as a modified building block for introducing reactive azide groups into DNA or RNA strands during solid-phase synthesis.
• Bioconjugation & Labeling: Enables the site-specific attachment of fluorophores, biotin, peptides, or other molecules to nucleic acids via click chemistry.
• Antisense & siRNA Therapeutics: Used in the research and development of therapeutic oligonucleotides requiring chemical modification for stability or targeting.
• Chemical Biology Probes: Facilitates the creation of activity-based probes to study nucleic acid-protein interactions and cellular processes.
• Materials Science: Serves as a precursor for creating functionalized surfaces or nanomaterials with nucleic acid components.
• Academic & Industrial R&D: A critical reagent for exploring novel nucleic acid architectures and drug delivery systems.

Basic Information

Product Name	5-Azidomethyl-2',3',5'-Tri-o-Benzoyl Uridine
CAS No.	1884334-72-8
Molecular Formula	C33H27N5O9
Molecular Weight	637.60 g/mol
Synonyms	5-(Azidomethyl)uridine 2',3',5'-tribenzoate; 2',3',5'-Tri-O-benzoyl-5-azidomethyluridine; 5-Azidomethyl-2',3',5'-tri-O-benzoyluridine; Uridine, 5-(azidomethyl)-2',3',5'-tris-O-benzoate; 5-N3Me-2',3',5'-tri-O-Bz-uridine; Protected 5-azidomethyluridine
EINECS	Contact for details

Quality Control

Every batch of 5-Azidomethyl-2',3',5'-Tri-o-Benzoyl Uridine is produced and tested under strict quality management protocols to ensure high purity and consistency for sensitive research and production applications. Our products undergo rigorous quality testing, including HPLC, NMR, and mass spectrometry analysis, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.