Description

Belinostat Z-Isomer is a specific stereoisomer of the histone deacetylase (HDAC) inhibitor Belinostat, a compound of significant interest in pharmaceutical research and development. This high-purity isomer is critical for advanced studies in oncology, particularly in understanding structure-activity relationships and metabolic pathways. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and contract manufacturing organizations (CMOs) focused on developing novel cancer therapeutics and conducting detailed pharmacokinetic analyses.

Application

• Pharmaceutical Reference Standard: Serves as a critical analytical standard for the identification, purity assessment, and quantification of the Z-isomer in Belinostat API and related formulations.
• Oncology Research: Used in biochemical and cellular assays to investigate the specific inhibitory activity, selectivity, and metabolic profile of the Z-isomer configuration against HDAC enzymes.
• Process Chemistry & Impurity Profiling: Essential for method development and validation in HPLC/LC-MS to monitor and control the Z-isomer as a potential process-related impurity during the synthesis of Belinostat (E-isomer).
• Metabolic Studies: Employed in in vitro and in vivo studies to trace the isomer-specific metabolism, stability, and pharmacokinetics of Belinostat derivatives.
• Drug Discovery & Development: A key intermediate or building block in the synthesis of novel HDAC inhibitor analogs and prodrugs for enhanced efficacy or reduced toxicity.

Basic Information

Product Name	Belinostat Z-Isomer
CAS No.	1884227-58-0
Molecular Formula	C15H14N2O4S
Molecular Weight	318.35 g/mol
Synonyms	PXD101 Z-Isomer; (Z)-Belinostat; (Z)-N-Hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide; (Z)-2-Propenamide, N-hydroxy-3-[3-[(phenylamino)sulfonyl]phenyl]-; Z-Isomer of PXD101; Z-Belinostat; (Z)-PXD101; Belinostat (cis-isomer)
EINECS	Contact for details

Quality Control

Our Belinostat Z-Isomer is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and isomer content, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports applications requiring high levels of analytical precision and reproducibility.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Isomeric Purity (Z-Isomer)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.