Description

Liarozole Dihydrochloride is a high-purity pharmaceutical intermediate and active compound. It serves as a critical building block in the research and development of novel therapeutic agents, particularly in oncology and dermatology. This compound is essential for pharmaceutical manufacturers, research institutions, and CROs (Contract Research Organizations) engaged in drug discovery and synthesis. CAS number is provided separately in the table below.

Application

• Pharmaceutical Intermediate: Key starting material or intermediate in the synthesis of active pharmaceutical ingredients (APIs) for clinical research.
• Oncology Research: Investigated for its potential role in cancer therapy development, particularly in modulating retinoic acid metabolism.
• Dermatological Agent Development: Used in research for developing treatments for skin conditions such as psoriasis and ichthyosis.
• Biochemical Research: Serves as a potent reference standard and tool compound for studying cytochrome P450 enzyme inhibition and retinoid signaling pathways.
• Preclinical Studies: Utilized in in vitro and in vivo studies to evaluate pharmacokinetics, efficacy, and safety profiles.
• GMP Manufacturing: Supplied as a qualified raw material for cGMP (current Good Manufacturing Practice) production of investigational new drugs.

Basic Information

Product Name	Liarozole Dihydrochloride
CAS No.	1883548-96-6
Molecular Formula	C₁₇H₁₄Cl₂N₄O
Molecular Weight	369.22 g/mol
Synonyms	Liarozole HCl; Liarozole dihydrochloride; (S)-Liarozole dihydrochloride; R 75251 dihydrochloride; 1-[(4-Chlorophenyl)(1H-imidazol-1-yl)methyl]-1H-benzimidazole dihydrochloride; (S)-1-[(4-Chlorophenyl)(1H-imidazol-1-yl)methyl]-1H-benzimidazole hydrochloride; R-85246; Liarozole (dihydrochloride)
EINECS	Contact for details

Quality Control

Our Liarozole Dihydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines to support our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.