Description

Alflutinib is a potent and selective third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. This compound is of significant interest for its targeted mechanism of action against specific EGFR mutations, including T790M, which is associated with resistance to earlier-generation therapies. It is primarily utilized by pharmaceutical R&D departments, biotechnology firms, and academic research institutions engaged in oncology drug discovery and development.

Application

• Oncological Research: A key investigational agent in preclinical and clinical studies targeting non-small cell lung cancer (NSCLC) with EGFR mutations.
• Drug Discovery & Development: Serves as a reference standard and active pharmaceutical ingredient (API) in the development of novel targeted cancer therapies.
• Biochemical Assays: Used as a potent inhibitor in enzymatic and cellular assays to study EGFR signaling pathways and mechanisms of drug resistance.
• Pharmacology Studies: Employed in pharmacokinetic (PK), pharmacodynamic (PD), and metabolism studies to understand its efficacy and safety profile.
• Academic Research: A vital tool for molecular and cancer biologists investigating tyrosine kinase function and targeted intervention strategies.

Basic Information

Product Name	Alflutinib
CAS No.	1869057-83-9
Molecular Formula	C₂₄H₂₅ClFN₅O₃
Molecular Weight	485.94 g/mol
Synonyms	AST2818; Alflutinib Mesylate; Alflutinib (AST2818); (R,E)-N-(4-(3-Chloro-4-fluorophenylamino)-7-ethoxyquinazolin-6-yl)-4-(dimethylamino)but-2-enamide; (R,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-4-(dimethylamino)but-2-enamide; 1869057-83-9; EGFR Inhibitor (T790M)
EINECS	Contact for details

Quality Control

Our Alflutinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. Certificates of Analysis (COA) with detailed specifications are provided to ensure compliance with research-grade standards and support regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the product label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.