Description

Abiraterone Acetate 5,6-Epoxide/(3β,5α,6α)-5,6-Epoxy-17-(3-Pyridinyl)-3-Androst-16-En-3-Ol-3-Acetate is a high-purity, advanced pharmaceutical intermediate and reference standard. This compound is critical for research and development in oncology, specifically in the synthesis and study of next-generation therapeutic agents targeting hormone-dependent cancers. It is essential for pharmaceutical manufacturers, contract research organizations (CROs), and academic laboratories engaged in the development of novel anti-cancer drugs and analytical method validation.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the production of advanced abiraterone analogs and metabolites for oncology research.
• Reference Standard: Used as a certified reference material (CRM) for quality control, analytical method development, and validation in pharmaceutical laboratories.
• Metabolite Studies: Critical for in-vitro and in-vivo pharmacokinetic and pharmacodynamic studies to understand drug metabolism pathways.
• Process Chemistry: Serves as a building block in the research-scale synthesis of novel steroidal compounds with potential therapeutic activity.
• Impurity Profiling: Employed as an impurity marker or degradation product standard to ensure the purity and safety of active pharmaceutical ingredients (APIs).
• Biochemical Research: Tool compound for investigating the mechanism of action and inhibition of cytochrome P450 enzymes, such as CYP17A1.

Basic Information

Product Name	Abiraterone Acetate 5,6-Epoxide/(3β,5α,6α)-5,6-Epoxy-17-(3-Pyridinyl)-3-Androst-16-En-3-Ol-3-Acetate
CAS No.	1868064-50-9
Molecular Formula	C26H31NO4
Molecular Weight	421.53 g/mol
Synonyms	(3β,5α,6α)-5,6-Epoxy-17-(3-pyridinyl)-3-androst-16-en-3-ol 3-acetate; Abiraterone acetate 5,6-epoxide; 5,6α-Epoxyabiraterone acetate; 17-(3-Pyridinyl)androsta-5,16-dien-3β-yl acetate 5,6-epoxide; Abiraterone acetate epoxide; ZYTIGA® metabolite derivative; CYP17A1 inhibitor intermediate
EINECS	Contact for details

Quality Control

Our Abiraterone Acetate 5,6-Epoxide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis to ensure compliance with ICH guidelines and customer-specific requirements. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature of 15-25°C to prevent oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.