Description

Ilorasertib Hydrochloride CAS NO 1847485-91-9 is a potent and selective small molecule inhibitor targeting Aurora kinases, which are key regulators of cell division. This compound is of significant interest for its potential in oncology research and therapeutic development, particularly in targeting cancers with dysregulated mitosis. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and academic research institutions focused on cancer biology, kinase inhibitor discovery, and preclinical drug development.

Application

• Oncology Research & Drug Discovery: A key tool compound for studying the role of Aurora kinases (A, B, C) in cell cycle progression, mitosis, and tumorigenesis.
• Biochemical Assay Development: Used as a reference standard in high-throughput screening (HTS) and enzymatic assays to identify and characterize novel kinase inhibitors.
• Preclinical Studies: Employed in in vitro and in vivo models to evaluate antitumor efficacy, pharmacokinetics, and pharmacodynamics of Aurora kinase inhibition.
• Mechanism of Action (MoA) Studies: Essential for investigating signaling pathways, synthetic lethality, and combination therapies in various cancer cell lines.
• Pharmaceutical Intermediate: Serves as a critical active pharmaceutical ingredient (API) intermediate in the synthesis of developmental cancer therapeutics.
• Academic Research: Used in university and institutional labs for fundamental research into mitosis, chromosome segregation, and cancer biology.

Basic Information

Product Name	Ilorasertib Hydrochloride
CAS No.	1847485-91-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	ABT-348 hydrochloride; Aurora Kinase Inhibitor ABT-348; 4-(4-((4-(Morpholin-4-yl)phenyl)amino)pyrrolo[2,1-f][1,2,4]triazin-5-yl)benzonitrile hydrochloride; ABT348 HCl; Ilorasertib HCl
EINECS	Contact for details

Quality Control

Our Ilorasertib Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) that include data from HPLC, NMR, and MS analysis, confirming compliance with research-grade specifications. Our quality commitment supports reliable and reproducible results in your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.