Description

Mobocertinib is a potent and selective small-molecule tyrosine kinase inhibitor (TKI) designed to target specific oncogenic mutations. This compound is of significant interest in pharmaceutical research and development for its targeted therapeutic potential. It is primarily utilized by research institutions, pharmaceutical developers, and contract manufacturing organizations (CMOs) engaged in the discovery and production of novel oncology treatments.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of targeted cancer therapeutics.
• Oncology Research: Used as a reference standard or active compound in preclinical studies and biochemical assays to investigate efficacy and mechanisms of action.
• Drug Discovery & Development: Employed in hit-to-lead optimization and candidate selection processes for novel EGFR inhibitor programs.
• Clinical Trial Material (CTM) Manufacturing: Supplied as a high-purity active pharmaceutical ingredient (API) for the production of formulations used in clinical studies.
• Academic Research: Utilized in university and institutional labs for fundamental research on kinase signaling pathways and resistance mechanisms.

Basic Information

Product Name	Mobocertinib
CAS No.	1847461-43-1
Molecular Formula	C27H27N5O3
Molecular Weight	469.54 g/mol
Synonyms	TAK-788; AP32788; Mobocertinib succinate; (1R,2s)-N-(3-{[5-Chloro-2-({2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}amino)pyrimidin-4-yl]oxy}phenyl)-2-hydroxycyclopentane-1-carboxamide; EXKIVITY (brand name)
EINECS	Contact for details

Quality Control

Our Mobocertinib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods (IR, NMR, MS), to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) documenting full compliance are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤20 ppm
Assay (HPLC)	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.