Description

1-Isothiocyanato-Peg4-Alcohol is a heterobifunctional polyethylene glycol (PEG) derivative featuring an isothiocyanate group and a terminal hydroxyl group, separated by a tetraethylene glycol spacer. This molecular architecture is critical for creating stable conjugates, as the isothiocyanate moiety readily reacts with primary amines to form thiourea bonds. It serves as a versatile linker and spacer molecule in bioconjugation and materials science, enabling the controlled attachment of biomolecules, dyes, or drugs to surfaces, nanoparticles, or other polymers. Key industries that utilize this compound include pharmaceutical development for antibody-drug conjugates (ADCs), diagnostic kit manufacturing, and advanced polymer research.

Application

• Bioconjugation Linker: For coupling peptides, proteins, or antibodies to solid supports, fluorophores, or drug molecules in therapeutic and diagnostic agent development.
• ADC (Antibody-Drug Conjugate) Payload Attachment: Acts as a cleavable or non-cleavable linker to connect cytotoxic drugs to targeting antibodies.
• Surface Functionalization: Modification of nanoparticles, quantum dots, or biosensor surfaces to introduce reactive hydroxyl groups for further chemistry.
• Polymer Chemistry Building Block: Used as a monomer or cross-linker in the synthesis of functionalized PEG-based hydrogels and smart materials.
• Diagnostic Reagent Synthesis: Preparation of enzyme or fluorescently labeled antibodies and antigens for ELISA, flow cytometry, and immunohistochemistry.
• Protein Immobilization: Covalent attachment of enzymes or other proteins to chromatographic media or microplates for assay development.

Basic Information

Product Name	1-Isothiocyanato-Peg4-Alcohol
CAS No.	1835759-69-7
Molecular Formula	C11H21NO6S
Molecular Weight	295.35 g/mol
Synonyms	4,7,10,13-Tetraoxa-16-azaheptadecan-17-yl isothiocyanate; 17-Isothiocyanato-4,7,10,13-tetraoxaheptadecan-1-ol; 2-[2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethyl isothiocyanate; PEG4-Alcohol-Isothiocyanate; Isothiocyanate-PEG4-OH; ITC-PEG4-OH; HO-PEG4-NCS; SC-PEG4-OH
EINECS	Contact for details

Quality Control

Our 1-Isothiocyanato-Peg4-Alcohol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and bioconjugation applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic and moisture-sensitive nature, containers should be sealed under an inert atmosphere (e.g., nitrogen or argon) after each use to prevent degradation. Keep away from strong bases and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.