Description

n-(2-((2-(Dimethylamino)Ethyl)(Methyl)Amino)-4-Methoxy-5-((4-(1-(2,2,2-Trifluoroethyl)-1H-Indol-3-Yl)Pyrimidin-2-Yl)Amino)Phenyl)Acrylamide is a high-purity, advanced pharmaceutical intermediate designed for targeted therapeutic development. This compound is critical for research and production in precision medicine, offering a key building block for novel kinase inhibitors. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on oncology and targeted therapy applications.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the production of novel, targeted small-molecule therapeutics.
• Kinase Inhibitor Research: Used as a core scaffold in the discovery and development of potent and selective kinase inhibitors for oncology.
• Preclinical & Clinical Development: Essential for formulating active pharmaceutical ingredients (APIs) during non-clinical studies and clinical trial material manufacturing.
• Biochemical Assay Development: Employed as a reference standard or probe compound in high-throughput screening and mechanism-of-action studies.
• Process Chemistry & Scale-Up: Supports route scouting, optimization, and kilogram-scale synthesis for commercial drug production.
• Academic Research: Utilized in university and institutional labs for studying structure-activity relationships (SAR) and signal transduction pathways.

Basic Information

Product Name	n-(2-((2-(Dimethylamino)Ethyl)(Methyl)Amino)-4-Methoxy-5-((4-(1-(2,2,2-Trifluoroethyl)-1H-Indol-3-Yl)Pyrimidin-2-Yl)Amino)Phenyl)Acrylamide
CAS No.	1835667-63-4
Molecular Formula	C29H32F3N7O2
Molecular Weight	567.61 g/mol
Synonyms	N-[2-[[2-(Dimethylamino)ethyl](methyl)amino]-4-methoxy-5-[[4-[1-(2,2,2-trifluoroethyl)indol-3-yl]pyrimidin-2-yl]amino]phenyl]prop-2-enamide; (E)-N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-(2,2,2-trifluoroethyl)-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide; CAS 1835667-63-4; Kinase Inhibitor Intermediate 1835667-63-4; Acrylamide-based kinase inhibitor precursor; 1-(2,2,2-Trifluoroethyl)-3-[2-({5-[(E)-3-(acryloylamino)-2-({2-[dimethylamino]ethyl}(methyl)amino)-4-methoxyphenyl]amino}pyrimidin-4-yl)]-1H-indole
EINECS	Contact for details

Quality Control

Our n-(2-((2-(Dimethylamino)Ethyl)(Methyl)Amino)-4-Methoxy-5-((4-(1-(2,2,2-Trifluoroethyl)-1H-Indol-3-Yl)Pyrimidin-2-Yl)Amino)Phenyl)Acrylamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements, including ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and opened under inert atmosphere or controlled humidity conditions when necessary for handling.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.