Description

2-(2,6-Dichlorophenyl)-2,2-Difluoroethan-1-Ol is a high-purity fluorinated aromatic intermediate of significant interest in advanced organic synthesis. This compound matters for its role as a key building block in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where the difluoroethanol moiety can impart desirable metabolic stability and bioavailability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate this unique fluorinated motif into their target molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and fungicides, where the difluoro group enhances biological activity and environmental persistence.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts used in asymmetric synthesis, leveraging the stereogenic center.
• Material Science Research: Employed in the creation of fluorinated monomers or additives for specialty polymers to modify surface properties and chemical resistance.
• Fluorine Chemistry Studies: An important substrate for investigating new fluorination methodologies and studying the effects of fluorine substitution on chemical reactivity.

Basic Information

Product Name	2-(2,6-Dichlorophenyl)-2,2-Difluoroethan-1-Ol
CAS No.	1824000-39-6
Molecular Formula	C8H6Cl2F2O
Molecular Weight	227.04 g/mol
Synonyms	2,2-Difluoro-2-(2,6-dichlorophenyl)ethanol; 2-(2,6-Dichlorophenyl)-2,2-difluoroethanol; α,α-Difluoro-2,6-dichlorobenzeneethanol; 1-(2,6-Dichlorophenyl)-2,2-difluoroethan-1-ol; (2,6-Dichlorophenyl)difluoromethyl carbinol
EINECS	Contact for details

Quality Control

Our 2-(2,6-Dichlorophenyl)-2,2-Difluoroethan-1-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request. We support development and scale-up with custom purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider the use of desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.