Description

Ethyl 2-(3,4-Difluorophenyl)Cyclopropanecarboxylate is a high-purity fluorinated cyclopropane derivative, a crucial advanced intermediate in modern organic synthesis. Its value lies in the unique structural motif of the cyclopropane ring fused with a difluorophenyl group, which is instrumental for modulating the biological activity and physicochemical properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to incorporate fluorinated cyclopropane scaffolds into new active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and fungicides, where the fluorinated cyclopropane structure can enhance efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized chiral ligands or organocatalysts used in asymmetric synthesis.
• Material Science Research: Investigated as a monomer or additive for developing specialty polymers with tailored thermal and chemical resistance properties.
• Chemical Biology Probes: Utilized in the design of molecular probes to study enzyme mechanisms or biological pathways due to its fluorinated aromatic system.

Basic Information

Item	Details
Product Name	Ethyl 2-(3,4-Difluorophenyl)Cyclopropanecarboxylate
CAS No.	1822784-83-7
Molecular Formula	C₁₂H₁₂F₂O₂
Molecular Weight	226.22 g/mol
Synonyms	Ethyl 2-(3,4-difluorophenyl)cyclopropanecarboxylate; 2-(3,4-Difluorophenyl)cyclopropanecarboxylic Acid Ethyl Ester; Ethyl 2-(3,4-Difluorophenyl)cyclopropanecarboxylate; (1R,2S)- or (1S,2R)-Ethyl 2-(3,4-difluorophenyl)cyclopropanecarboxylate (enantiomers); Ethyl 2-(3,4-difluorophenyl)cyclopropane-1-carboxylate; 3,4-Difluorophenylcyclopropanecarboxylic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Every batch of Ethyl 2-(3,4-Difluorophenyl)Cyclopropanecarboxylate is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure compliance with stringent in-house specifications, which are aligned with the needs of advanced R&D and scale-up processes. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong acids and incompatible materials such as strong oxidizing agents. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation (if chiral)	Contact for details
Enantiomeric Excess (if applicable)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.