Description

Propargyl-Peg1-Ss-Peg1-Pfp Ester is a specialized heterobifunctional crosslinker featuring a propargyl group for copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry and a pentafluorophenyl (PFP) ester for efficient amine coupling. This compound is a critical reagent for the site-specific conjugation of biomolecules, enabling the construction of complex, defined architectures. It is primarily utilized by researchers and process developers in bioconjugation, pharmaceutical development, and advanced materials science to create stable, functionalized peptides, proteins, and polymers.

Application

• Bioconjugation and ADC Development: Site-specific conjugation of cytotoxic payloads to antibodies for Antibody-Drug Conjugate (ADC) synthesis.
• Peptide and Protein Modification: Introduction of alkyne handles onto amine-containing biomolecules for subsequent click chemistry labeling or immobilization.
• Polymer Functionalization: Synthesis of functionalized PEG derivatives and smart polymeric materials with tailored reactivity.
• Surface Immobilization: Crafting biofunctional surfaces and sensor chips by conjugating biomolecules via amine-reactive chemistry.
• Diagnostic Reagent Synthesis: Preparation of labeled probes and reagents for imaging and diagnostic assays.
• Chemical Biology Tool Development: Creating molecular probes for studying protein interactions and cellular processes.
• Hydrogel Formation: Cross-linking agent for creating biocompatible hydrogel networks with controlled properties.
• Nanoparticle Functionalization: Attaching targeting ligands or functional molecules to nanoparticle surfaces.

Basic Information

Product Name	Propargyl-Peg1-Ss-Peg1-Pfp Ester
CAS No.	1817735-30-0
Molecular Formula	C18H18F5NO5S2
Molecular Weight	487.46 g/mol
Synonyms	1-(2-(2-(2,3,5,6-Tetrafluoro-4-(2,3,5,6-tetrafluorophenoxy)phenoxy)ethoxy)ethyl 2-(prop-2-yn-1-ylthio)ethyl carbonotrithioate; Propargyl-PEG1-SS-PEG1-PFP ester; PFP-PEG1-SS-PEG1-Propargyl; Pentafluorophenyl ester-PEG1-disulfide-PEG1-propargyl; Heterobifunctional crosslinker SS-PEG1-PFP/Propargyl; Alkyne-PEG1-SS-PEG1-PFP Ester; Propargyl-PEG1-disulfide-PEG1-PFP; Amine and Alkyne Reactive Crosslinker
EINECS	Contact for details

Quality Control

Every batch of Propargyl-Peg1-Ss-Peg1-Pfp Ester is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and performance. Our products are supported by a detailed Certificate of Analysis (COA) that includes data from HPLC, NMR, and mass spectrometry. We adhere to high-purity standards suitable for research and development applications, with specifications available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or oil
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with molecular structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.