Description

Valemetostat Tosylate is a potent and selective small molecule inhibitor of the Enhancer of Zeste Homolog 2 (EZH1) and EZH2 methyltransferases. This compound is critical for advancing research and development in oncology, specifically targeting epigenetic dysregulation in various cancers. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and contract manufacturing organizations (CMOs) focused on developing novel therapeutics for hematological malignancies and solid tumors.

Application

• Oncological Research: Key investigational agent for studying the role of EZH1/2 inhibition in cancer cell proliferation and survival.
• Preclinical Development: Used in in vitro and in vivo studies to evaluate pharmacokinetics, pharmacodynamics, and efficacy.
• Drug Substance (API) Manufacturing: Serves as the active pharmaceutical ingredient in the production of clinical trial materials.
• Mechanism of Action Studies: A tool compound for elucidating epigenetic pathways and their contribution to oncogenesis.
• Combination Therapy Research: Investigated in conjunction with other anticancer agents to assess synergistic effects.
• Biomarker Discovery: Aids in identifying predictive biomarkers for patient stratification in targeted therapy.

Basic Information

Product Name	Valemetostat Tosylate
CAS No.	1809336-93-3
Molecular Formula	C33H44N4O7S
Molecular Weight	640.79 g/mol
Synonyms	DS-3201; DS 3201; DS3201; Valemetostat ditosylate; (R)-N-((1,2-Dihydroacenaphthylen-5-yl)methyl)-1-methoxy-6,6-dimethyl-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole-3-carboxamide ditosylate; EZH1/2 Dual Inhibitor
EINECS	Contact for details

Quality Control

Our Valemetostat Tosylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation (IR, NMR, MS) to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool place. This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.